Cyclic GMP in the retinas of normal mice and those heterozygous for early-onset photoreceptor dystrophy
M Doshi, MJ Voaden, GB Arden - Experimental eye research, 1985 - Elsevier
Cyclic GMP metabolism has been investigated in the retinas of mice that are heterozygous
for a 'photoreceptor dystrophy'gene and have a lowered concentration of cGMP in their
photoreceptor cells. The concentration of rhodopsin, retinal morphology and guanylate
cyclase kinetics were normal. Cyclic GMP phosphodiesterase had a lowered affinity for
cGMP. In accord with previous observations, chelation of exogenous calcium had no effect
on cGMP levels in light-adapted retinas but increased them in dark-adapted tissue. The …
for a 'photoreceptor dystrophy'gene and have a lowered concentration of cGMP in their
photoreceptor cells. The concentration of rhodopsin, retinal morphology and guanylate
cyclase kinetics were normal. Cyclic GMP phosphodiesterase had a lowered affinity for
cGMP. In accord with previous observations, chelation of exogenous calcium had no effect
on cGMP levels in light-adapted retinas but increased them in dark-adapted tissue. The …
